ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans

Ataxin-3 is the protein involved in Machado-Joseph disease, a neurodegenerative disorder caused by a polyglutamine expansion. Ataxin-3 binds ubiquitylated proteins and acts as a deubiquitylating enzyme in vitro. It was previously proposed that ataxin-3, along with the VCP/p97 protein, escorts ubiqui...

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Bibliographic Details
Main Author: Rodrigues, Ana João (author)
Other Authors: Carvalho, Andreia Alexandra Neves (author), Ferro, Anabela (author), Rokka, Anne (author), Corthals, Garry (author), Logarinho, Elsa (author), Maciel, P. (author)
Format: article
Language:eng
Published: 2009
Subjects:
Adaptor proteins, Signal transducing
Adenosine triphosphatases
Animals
Ataxin-3
Caenorhabditis elegans
Caenorhabditis elegans proteins
Cell cycle proteins
Multiprotein complexes
Nerve tissue proteins
Protein interaction domains and motifs
Protein interaction mapping
Valosin containing protein
Polyglutamine
Machado–Joseph disease
Spinocerebellar ataxia type 3
Ubiquitin–proteasome pathway
Deubiquitylating enzyme
Science & Technology
Online Access:http://hdl.handle.net/1822/67644
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67644

Internet

http://hdl.handle.net/1822/67644

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