Safety profile of solid lipid nanoparticles loaded with rosmarinic acid for oral use: in vitro and animal approaches

Rosmarinic acid (RA) possesses several protective bioactivities that have attracted increasing interest by nutraceutical/pharmaceutical industries. Considering the reduced bioavailability after oral use, effective (and safe) delivery systems are crucial to protect RA from gastrointestinal degradatio...

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Bibliographic Details
Main Author: Reis, Flávio (author)
Other Authors: Madureira, Ana Raquel (author), Nunes, Sara (author), Campos, Débora (author), Fernandes, João (author), Marques, Cláudia (author), Zuzarte, Monica (author), Gullón, Beatriz (author), Rodríguez-Alcalá, Luis M. (author), Calhau, Conceição (author), Sarmento, Bruno (author), Gomes, Ana M. (author), Pintado, M. E. (author)
Format: article
Language:eng
Published: 2017
Subjects:
Solid lipid nanoparticles
Rosmarinic acid
Witepsol and Carnauba waxes
Safety profile
In vitro and animal toxicity
Online Access:http://hdl.handle.net/10400.14/23085
Country:Portugal
Oai:oai:repositorio.ucp.pt:10400.14/23085

Internet

http://hdl.handle.net/10400.14/23085

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