Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Parkinson’s disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of -synuclein (a-syn) in various brain regions is themajorpathological hallmark. Indeed, themotorsymptomsinPDare causedby a heterogeneous degeneration of...

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Detalhes bibliográficos
Autor principal: Diógenes, Maria José (author)
Outros Autores: Dias, Raquel B. (author), Rombo, Diogo M. (author), Miranda, Hugo Vicente (author), Maiolino, Francesca (author), Guerreiro, Patrícia (author), Näsström, Thomas (author), Franquelim, Henri G. (author), Oliveira, Luis M. A. (author), Castanho, Miguel A. R. B. (author), Lannfelt, Lars (author), Bergström, Joakim (author), Ingelsson, Martin (author), Quintas, Alexandre (author), Sebastião, Ana M. (author), Lopes, Luísa V. (author), Outeiro, Tiago Fleming (author)
Formato: article
Idioma:eng
Publicado em: 2013
Assuntos:
Alpha-synuclein
a-syn oligomers
Parkinson's disease
Texto completo:http://hdl.handle.net/10400.26/4825
País:Portugal
Oai:oai:comum.rcaap.pt:10400.26/4825

Texto Completo

http://hdl.handle.net/10400.26/4825

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