Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

Naïve FoxP3-expressing regulatory T-cells (Tregs) are essential to control immune responses via continuous replenishment of the activated-Treg pool with thymus-committed suppressor cells. The mechanisms underlying naïve-Treg maintenance throughout life in face of the age-associated thymic involution...

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Bibliographic Details
Main Author: Silva, Susana L. (author)
Other Authors: Albuquerque, Adriana S. (author), Serra-Caetano, Ana (author), Foxall, Russell B. (author), Pires, Ana R. (author), Matoso, Paula (author), Fernandes, Susana M. (author), Ferreira, João (author), Cheynier, Rémi (author), Victorino, Rui M. M. (author), Caramalho, Iris (author), Barata, João T. (author), Sousa, Ana E. (author)
Format: article
Language:eng
Published: 2016
Subjects:
IL-7
Immune response
Human regulatory T-cells
Naïve regulatory T-cells
Regulatory T-cell homeostasis
Thymectomy
Online Access:http://hdl.handle.net/10451/24384
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/24384

Internet

http://hdl.handle.net/10451/24384

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