Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7

Naïve FoxP3-expressing regulatory T-cells (Tregs) are essential to control immune responses via continuous replenishment of the activated-Treg pool with thymus-committed suppressor cells. The mechanisms underlying naïve-Treg maintenance throughout life in face of the age-associated thymic involution...

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Detalhes bibliográficos
Autor principal: Silva, Susana L. (author)
Outros Autores: Albuquerque, Adriana S. (author), Serra-Caetano, Ana (author), Foxall, Russell B. (author), Pires, Ana R. (author), Matoso, Paula (author), Fernandes, Susana M. (author), Ferreira, João (author), Cheynier, Rémi (author), Victorino, Rui M. M. (author), Caramalho, Iris (author), Barata, João T. (author), Sousa, Ana E. (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
IL-7
Immune response
Human regulatory T-cells
Naïve regulatory T-cells
Regulatory T-cell homeostasis
Thymectomy
Texto completo:http://hdl.handle.net/10451/24384
País:Portugal
Oai:oai:repositorio.ul.pt:10451/24384

Texto Completo

http://hdl.handle.net/10451/24384

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