Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells

Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling products to the corresponding amino compounds. The a...

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Detalhes bibliográficos
Autor principal: Calhelha, Ricardo C. (author)
Outros Autores: Ferreira, Isabel C.F.R. (author), Peixoto, Daniela (author), Abreu, Rui M.V. (author), Vale-Silva, Luís A. (author), Pinto, Eugénia (author), Lima, Raquel T. (author), Alvelos, M. Inês (author), Vasconcelos, M. Helena (author), Queiroz, Maria João R.P. (author)
Formato: article
Idioma:eng
Publicado em: 2012
Assuntos:
Thieno[3,2-b]pyridines
Aminodi(hetero)arylamines
Buchwald-Hartwig C-N coupling
Antitumoral activity
Toxicity
Cell cycle
Texto completo:http://hdl.handle.net/10198/7370
País:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/7370

Texto Completo

http://hdl.handle.net/10198/7370

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