Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteolysis in the Pathway to Disease
Transthyretin amyloidosis is a conformational pathology characterized by the extracellular formation of amyloid deposits and the progressive impairment of the peripheral nervous system. Point mutations in this tetrameric plasma protein decrease its stability and are linked to disease onset and progr...
Main Author: | |
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Other Authors: | , , , , , , , , , |
Format: | article |
Language: | eng |
Published: |
2015
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Subjects: | |
Online Access: | http://hdl.handle.net/10400.17/2291 |
Country: | Portugal |
Oai: | oai:repositorio.chlc.min-saude.pt:10400.17/2291 |