Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteolysis in the Pathway to Disease

Transthyretin amyloidosis is a conformational pathology characterized by the extracellular formation of amyloid deposits and the progressive impairment of the peripheral nervous system. Point mutations in this tetrameric plasma protein decrease its stability and are linked to disease onset and progr...

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Bibliographic Details
Main Author: Costa, G (author)
Other Authors: Ribeiro-Silva, C (author), Ribeiro, R (author), Gilberto, S (author), Gomes, R (author), Ferreira, A (author), Mateus, E (author), Barroso, E (author), Coelho, A (author), Ponces Freire, A (author), Cordeiro, C (author)
Format: article
Language:eng
Published: 2015
Subjects:
Amino Acid Sequence
HCC CHBPT
Amyloid Neuropathies, Familial/blood
Amyloid Neuropathies, Familial/metabolism
Blood Proteins/chemistry
Case-Control Studies
Electrophoresis, Gel, Two-Dimensional
Molecular Chaperones/metabolism
Molecular Sequence Data
Proteolysis
Proteomics
Sequence Homology, Amino Acid
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Online Access:http://hdl.handle.net/10400.17/2291
Country:Portugal
Oai:oai:repositorio.chlc.min-saude.pt:10400.17/2291

Internet

http://hdl.handle.net/10400.17/2291

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