Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

Sirtuins (SIRT1-7), a class of NAD+-dependent deacylases, are central regulators of metabolic homeostasis and stress responses. While numerous salutary effects associated with sirtuin activation, especially SIRT1, are well documented, other reports show health benefits resulting from sirtuin inhibit...

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Bibliographic Details
Main Author: Gomes, Pedro (author)
Other Authors: Leal, Helena (author), Mendes, Alexandrina F. (author), Reis, Flávio (author), Cavadas, Cláudia (author)
Format: article
Language:por
Published: 2019
Subjects:
age-related diseases; cardiometabolic diseases; genetic manipulations; neurodegeneration; pharmacological modulators; sirtuins
Online Access:http://hdl.handle.net/10316/87807
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/87807

Internet

http://hdl.handle.net/10316/87807

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