Dichotomous Sirtuins: Implications for Drug Discovery in Neurodegenerative and Cardiometabolic Diseases

Sirtuins (SIRT1-7), a class of NAD+-dependent deacylases, are central regulators of metabolic homeostasis and stress responses. While numerous salutary effects associated with sirtuin activation, especially SIRT1, are well documented, other reports show health benefits resulting from sirtuin inhibit...

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Detalhes bibliográficos
Autor principal: Gomes, Pedro (author)
Outros Autores: Leal, Helena (author), Mendes, Alexandrina F. (author), Reis, Flávio (author), Cavadas, Cláudia (author)
Formato: article
Idioma:por
Publicado em: 2019
Assuntos:
age-related diseases; cardiometabolic diseases; genetic manipulations; neurodegeneration; pharmacological modulators; sirtuins
Texto completo:http://hdl.handle.net/10316/87807
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/87807

Texto Completo

http://hdl.handle.net/10316/87807

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