Hybrid dynamic modeling of Escherichia coli central metabolic network combining Michaelis–Menten and approximate kinetic equations

The construction of dynamic metabolic models at reaction network level requires the use of mechanistic enzymatic rate equations that comprise a large number of parameters. The lack of knowledge on these equations and the difficulty in the experimental identification of their associated parameters, r...

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Bibliographic Details
Main Author: Costa, Rafael S. (author)
Other Authors: Machado, C. D. (author), Rocha, I. (author), Ferreira, Eugénio C. (author)
Format: article
Language:eng
Published: 2010
Subjects:
Online Access:https://hdl.handle.net/1822/10690
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/10690