Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation

A central mechanism of tumour progression and metastasis involves the generation of an immunosuppressive 'macroenvironment' mediated in part through tumour-secreted factors. Here we demonstrate that upregulation of the Inhibitor of Differentiation 1 (Id1), in response to tumour-derived fac...

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Bibliographic Details
Main Author: Papaspyridonos, Marianna (author)
Other Authors: Matei, Irina (author), Huang, Yujie (author), Andre, Maria do Rosario (author), Brazier-Mitouart, Helene (author), Waite, Janelle C. (author), Chan, April S. (author), Kalter, Julie (author), Ramos, Ilyssa (author), Wu, Qi (author), Williams, Caitlin (author), Wolchok, Jedd D. (author), Chapman, Paul B. (author), Peinado, Hector (author), Anandasabapathy, Niroshana (author), Ocean, Allyson J. (author), Kaplan, Rosandra N. (author), Greenfield, Jeffrey P. (author), Bromberg, Jacqueline (author), Skokos, Dimitris (author), Lyden, David (author)
Format: article
Language:eng
Published: 2017
Subjects:
SELF-RENEWAL CAPACITY
REGULATORY T-CELLS
TGF-BETA
DENDRITIC CELLS
PERIPHERAL-BLOOD
PROGENITOR CELLS
CANCER-PATIENTS
DIFFERENTIATION
PROTEINS
MELANOMA
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
SDG 3 - Good Health and Well-being
Online Access:https://doi.org/10.1038/ncomms7840
Country:Portugal
Oai:oai:run.unl.pt:10362/23262

Internet

https://doi.org/10.1038/ncomms7840

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