Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation

The effect of the antiepileptic drug valproic acid (VPA) on mitochondrial oxidative phosphorylation (OXPHOS) was investigated in vitro. Two experimental approaches were used, in the presence of selected respiratory-chain Substrates: (1) formation of ATP i

Detalhes bibliográficos
Autor principal: Luis, Paula B. M. (author)
Outros Autores: Ruiter, Jos P. N. (author), Aires, Catia C. P. (author), Soveral, Graca (author), de Almelda, Isabel Tavares (author), Duran, Marinus (author), Wanders, Ronald J. A. (author), Silva, Margarida F. B. (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Biochemistry & Molecular Biology
Biophysics
Texto completo:http://hdl.handle.net/10451/21625
País:Portugal
Oai:oai:repositorio.ul.pt:10451/21625
Descrição
Resumo:The effect of the antiepileptic drug valproic acid (VPA) on mitochondrial oxidative phosphorylation (OXPHOS) was investigated in vitro. Two experimental approaches were used, in the presence of selected respiratory-chain Substrates: (1) formation of ATP i

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