Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation

The effect of the antiepileptic drug valproic acid (VPA) on mitochondrial oxidative phosphorylation (OXPHOS) was investigated in vitro. Two experimental approaches were used, in the presence of selected respiratory-chain Substrates: (1) formation of ATP i

Bibliographic Details
Main Author: Luis, Paula B. M. (author)
Other Authors: Ruiter, Jos P. N. (author), Aires, Catia C. P. (author), Soveral, Graca (author), de Almelda, Isabel Tavares (author), Duran, Marinus (author), Wanders, Ronald J. A. (author), Silva, Margarida F. B. (author)
Format: article
Language:eng
Published: 2015
Subjects:
Biochemistry & Molecular Biology
Biophysics
Online Access:http://hdl.handle.net/10451/21625
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21625
Description
Summary:The effect of the antiepileptic drug valproic acid (VPA) on mitochondrial oxidative phosphorylation (OXPHOS) was investigated in vitro. Two experimental approaches were used, in the presence of selected respiratory-chain Substrates: (1) formation of ATP i

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