Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

Defects in endolysosomal and autophagic functions are increasingly viewed as key pathological features of neurodegenerative disorders. A master regulator of these functions is phosphatidylinositol-3-phosphate (PI3P), a phospholipid synthesized primarily by class III PI 3-kinase Vps34. Here we report...

Full description

Bibliographic Details
Main Author: Miranda, André Miguel Lopes (author)
Other Authors: Lasiecka, Zofia M. (author), Xu, Yimeng (author), Neufeld, Jessi (author), Shahriar, Sanjid (author), Simoes, Sabrina (author), Chan, Robin B. (author), Oliveira, Tiago Gil (author), Small, Scott A. (author), Di Paolo, Gilbert (author)
Format: article
Language:eng
Published: 2018
Subjects:
Amyloid beta-Protein Precursor
Animals
Autophagy
Biomarkers
Cell Line, Tumor
Class III Phosphatidylinositol 3-Kinases
Exosomes
HEK293 Cells
Humans
Lipids
Lysophospholipids
Lysosomes
Mice, Inbred C57BL
Mice, Knockout
Monoglycerides
Neurodegenerative Diseases
Neurons
Peptide Fragments
Phosphatidylinositol Phosphates
Ciências Médicas::Medicina Básica
Science & Technology
Online Access:http://hdl.handle.net/1822/57895
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/57895

Internet

http://hdl.handle.net/1822/57895

Similar Items