Glycogen synthase kinase 3 induces multilineage maturation of human pluripotent stem cell-derived lung progenitors in 3D culture

Although strategies for directed differentiation of human pluripotent stem cells (hPSCs) into lung and airway have been established, terminal maturation of the cells remains a vexing problem. We show here that in collagen I 3D cultures in the absence of glycogen synthase kinase 3 (GSK3) inhibition,...

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Detalhes bibliográficos
Autor principal: Carvalho, Ana Luisa Rodrigues Toste de (author)
Outros Autores: Strikoudis, Alexandros (author), Liu, Hsiao-Yun (author), Chen, Ya-Wen (author), Dantas, Tiago J. (author), Vallee, Richard B. (author), Correia-Pinto, Jorge (author), Snoeck, Hans-Willem (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Animals
Body Patterning
Cell Culture Techniques
Cell Cycle
Collagen Type I
Genome, Human
Glycogen Synthase Kinase 3
Humans
Induced Pluripotent Stem Cells
Lung
Mice
Pyridines
Receptors, Notch
Reproducibility of Results
Wnt Signaling Pathway
Cell Differentiation
Cell Lineage
Directed differentiation
Human lung development
Pluripotent stem cells
Science & Technology
Texto completo:http://hdl.handle.net/1822/62495
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/62495

Texto Completo

http://hdl.handle.net/1822/62495

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