3-Oxo-β-Sultams and 4-Oxo-β-Lactams as chemical tools for activity-based protein profiling of serine hydrolases

Activity-based protein profiling (ABPP) is a technique that analyzes the dynamics in enzymatic activity in complex proteomes by using small molecular probes, deemed activity-based probes (ABPs), containing a reactive group to covalently bind enzyme catalytic residues, a tag for detection of labeled...

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Bibliographic Details
Main Author: Carvalho, Luís Miguel Afonso Ramos de (author)
Format: doctoralThesis
Language:eng
Published: 2021
Subjects:
activity-based protein profiling
activity-based probe
serine hydrolase
4-Oxo-β-Lactam
3-Oxo-β-Sultam
Domínio/Área Científica::Ciências Médicas::Medicina Básica
Online Access:http://hdl.handle.net/10451/42844
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/42844

Internet

http://hdl.handle.net/10451/42844

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