Positive Epistasis Drives the Acquisition of Multidrug Resistance

The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact-epistasis. Information on the level of epistasis betw...

Full description

Bibliographic Details
Main Author: Trindade, S. (author)
Other Authors: Sousa, A. (author), Xavier, KB. (author), Dionisio, F. (author), Ferreira, MG. (author), Gordo, I. (author)
Format: article
Language:eng
Published: 2010
Subjects:
ANTIBIOTIC-RESISTANCE
ESCHERICHIA-COLI
MYCOBACTERIUM-TUBERCULOSIS
DELETERIOUS MUTATIONS
COMPENSATORY MUTATIONS
FITNESS COSTS
Online Access:http://hdl.handle.net/10400.7/194
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/194

Internet

http://hdl.handle.net/10400.7/194

Similar Items