Mutation ‘C11994T’ in the mitochondrial ND4 gene is not a cause of low sperm motility in Portugal

It has recently been suggested that a hitherto unobserved mutation, C11994T, causes oligoasthenozoospermia in men from India but at the same time does not affect systems other than the motility of the sperm. There are good reasons to question this proposition, in view of the worldwide mtDNA database...

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Detalhes bibliográficos
Autor principal: Pereira, L (author)
Outros Autores: Gonçalves, J (author), Bandelt, H-J (author)
Formato: article
Idioma:eng
Publicado em: 2008
Assuntos:
Asthenozoospermia/enzymology
Asthenozoospermia/genetics
Asthenozoospermia/physiopathology
DNA Mitochondrial
Genotype
Haplotypes
Humans
Male
Mitochondria/enzymology
Mutation
NADH Dehydrogenase/genetics
Oligospermia
Phenotype
Portugal
Sperm Motility/genetics
Spermatozoa/enzymology
Texto completo:http://hdl.handle.net/10216/109569
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/109569
Descrição
Resumo:It has recently been suggested that a hitherto unobserved mutation, C11994T, causes oligoasthenozoospermia in men from India but at the same time does not affect systems other than the motility of the sperm. There are good reasons to question this proposition, in view of the worldwide mtDNA database and the Indian record in particular. We have further analyzed the oligoasthenozoospermic samples from a previous systematic study of infertile Portuguese men and found no instance of C11994T.

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