The role of alternative splicing coupled to nonsense-mediated mRNA decay in human disease

Alternative pre-mRNA splicing (AS) affects gene expression as it generates proteome diversity. Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and selectively degrades mRNAs carrying premature translation-termination codons (PTCs), preventing the production of truncated...

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Detalhes bibliográficos
Autor principal: da Costa, Paulo (author)
Outros Autores: Menezes, Juliane (author), Romão, Luísa (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
AS Coupled to NMD (AS-NMD)
Alternative Splicing (AS)
Human Disease
Nonsense-mediated mRNA Decay (NMD)
Post-transcriptional cControl of Gene Expression
Genómica Funcional e Estrutural
Expressão Génica
Texto completo:http://hdl.handle.net/10400.18/5111
País:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5111

Texto Completo

http://hdl.handle.net/10400.18/5111

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