Unilateral intrastriatal 6-hydroxydopamine lesion in mice: a closer look into non-motor phenotype and glial response

Parkinson’s disease (PD) is a prevalent movement disorder characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). The 6-hydroxydopamine (6-OHDA) lesion is still one of the most widely used techniques for modeling Parkinson’s disease (PD) in rodents. De...

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Detalhes bibliográficos
Autor principal: Pinheiro, Bárbara Filipa Mendes (author)
Outros Autores: Cunha, Carina Isabel Soares (author), Marote, Ana Maria Franco Aveiro (author), Loureiro-Campos, Eduardo (author), Campos, Jonas Oliveira (author), Barata-Antunes, Sandra (author), Fernandes, Daniela Monteiro (author), Santos, Diogo Jorge Ferreira (author), Silva, Sara Carina Duarte (author), Pinto, Luísa (author), Salgado, A. J. (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Parkinson’s disease
6-OHDA
Unilateral
Striatum
Dopaminergic degeneration
Motor behavior
Non-motor behavior
Glial response
Science & Technology
Texto completo:http://hdl.handle.net/1822/75841
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/75841

Texto Completo

http://hdl.handle.net/1822/75841

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