Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations.

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mRNAs containing premature termination codons (PTC). The strength of the NMD response appears to reflect multiple determinants on a target mRNA. We have previously reported that mRNAs containing PTCs in...

Full description

Bibliographic Details
Main Author: Peixeiro, Isabel (author)
Other Authors: Inácio, Ângela (author), Barbosa, Cristina (author), Silva, Ana Luísa (author), Liebhaber, Stephen (author), Romão, Luísa (author)
Format: article
Language:eng
Published: 2011
Subjects:
Mammalian nonsense-mediated mRNA decay (NMD)
Translation initiation
AUG-proximal nonsense-mutated mRNAs
Poly(A)-binding protein (PABP)
Premature termination codon (PTC)
Genética funcional e estrutural
Online Access:http://hdl.handle.net/10400.18/334
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/334

Internet

http://hdl.handle.net/10400.18/334

Similar Items