Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

The virtual screening of a library of chalcone derivatives led us to the identification of potential new MDM2 ligands. The chalcones with the best docking scores obeying the Lipinski rule of five were subsequently prepared by base-catalyzed aldol reactions. The activity of these compounds as inhibit...

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Bibliographic Details
Main Author: Pereira, D (author)
Other Authors: Lima, RT (author), Palmeira, A (author), Seca, H (author), Soares, J (author), Gomes, S (author), Raimundo, L (author), Maciel, C (author), Pinto, M (author), Sousa, E (author), Vasconcelos, MH (author), Saraiva, L (author), Cidade, H (author)
Format: article
Language:eng
Published: 2019
Online Access:https://hdl.handle.net/10216/136285
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/136285

Internet

https://hdl.handle.net/10216/136285

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