Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

The virtual screening of a library of chalcone derivatives led us to the identification of potential new MDM2 ligands. The chalcones with the best docking scores obeying the Lipinski rule of five were subsequently prepared by base-catalyzed aldol reactions. The activity of these compounds as inhibit...

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Detalhes bibliográficos
Autor principal: Pereira, D (author)
Outros Autores: Lima, RT (author), Palmeira, A (author), Seca, H (author), Soares, J (author), Gomes, S (author), Raimundo, L (author), Maciel, C (author), Pinto, M (author), Sousa, E (author), Vasconcelos, MH (author), Saraiva, L (author), Cidade, H (author)
Formato: article
Idioma:eng
Publicado em: 2019
Texto completo:https://hdl.handle.net/10216/136285
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/136285

Texto Completo

https://hdl.handle.net/10216/136285

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