Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

Some strains of the protozoan parasite Toxoplasma gondii (such as RH) are virulent in laboratory mice because they are not restricted by the Immunity-Related GTPase (IRG) resistance system in these mouse strains. In some wild-derived Eurasian mice (such as CIM) on the other hand, polymorphic IRG pro...

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Bibliographic Details
Main Author: Murillo-León, Mateo (author)
Other Authors: Müller, Urs B (author), Zimmermann, Ines (author), Singh, Shishir (author), Widdershooven, Pia (author), Campos, Cláudia (author), Alvarez, Catalina (author), Könen-Waisman, Stephanie (author), Lukes, Nahleen (author), Ruzsics, Zsolt (author), Howard, Jonathan C (author), Schwemmle, Martin (author), Steinfeldt, Tobias (author)
Format: article
Language:eng
Published: 2020
Subjects:
Animals
Disease Resistance
Female
Fibroblasts
GTP Phosphohydrolases
HEK293 Cells
Host-Parasite Interactions
Humans
Male
Mice
Mice, Inbred C57BL
Protein Isoforms
Protozoan Proteins
Selection, Genetic
Toxoplasma
Toxoplasmosis, Animal
Virulence
Online Access:http://hdl.handle.net/10400.7/930
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/930

Internet

http://hdl.handle.net/10400.7/930

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