Zidovudine-poly(l-lactic acid) solid dispersions with improved intestinal permeability prepared by supercritical antisolvent process

A supercritical antisolvent (SAS) process for obtaining zidovudine-poly(l-lactic acid) (PLLA) solid dispersions (SDs) was used to attain a better intestinal permeation of this drug. A 32 factorial design was used, having as independent variables the ratio 3-azido-23-dideoxythymidine (AZT)PLLA and te...

ver descrição completa

Detalhes bibliográficos
Autor principal: Yoshida, Valquíria M. H. (author)
Outros Autores: Balcão, V. M. (author), Vila, Marta M. D. C. (author), Oliveira Júnior, J. M. (author), Aranha, Norberto (author), Chaud, Marco V. (author), Gremião, Maria P. D. (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
supercritical antisolvent process
supercritical fluids
zidovudine
poly(l-lactic acid)
solid dispersion
oral absorption
gastrointestinal transit
everted rat intestinal sacs
permeability
Ciências Médicas::Biotecnologia Médica
Science & Technology
Texto completo:http://hdl.handle.net/1822/35310
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/35310

Texto Completo

http://hdl.handle.net/1822/35310

Registros relacionados