Ga(III) chelates of amphiphilic DOTA-based ligands : synthetic route and in vitro and in vivo studies

In this work we report a synthetic strategy of amphiphilic DOTA-based chelators bearing a variable size α-alkyl chain at one of the pendant acetate arms (from six to fourteen carbon atoms), compatible with their covalent coupling to amine-bearing biomolecules. The amphiphilic behavior of the micelle...

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Bibliographic Details
Main Author: Fontes, André Filipe Gomes Soares (author)
Other Authors: Prata, M. Isabel M. (author), Geraldes, Carlos F. G. C. (author), André, João P. (author)
Format: article
Language:eng
Published: 2011
Subjects:
DOTA
Gallium
Amphiphilic
Micelles
Radiopharmacy
PET
Science & Technology
Online Access:http://hdl.handle.net/1822/14267
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/14267

Internet

http://hdl.handle.net/1822/14267

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