Evaluation of gastric toxicity of indomethacin acid, salt form and complexed forms with hydroxypropyl-beta-cyclodextrin on Wistar rats: histopathologic analysis

Indomethacin (IM) is a non-steroidal anti-inflammatory drug which inhibits prostaglandin biosynthesis. It is practically insoluble in water and has the capacity to induce gastric injury. Hydroxypropyl-b-cyclodextrin (HP-b-CD) is an alkylated derivative of b-CD with the capacity to form inclusion com...

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Bibliographic Details
Main Author: Rama, A. C. (author)
Other Authors: Figueiredo, Isabel Vitoria (author), Veiga, F. (author), Castel-Branco, M. M. (author), Cabrita, A. M. S. (author), Caramona, M. M. (author)
Format: article
Language:eng
Published: 2009
Subjects:
freeze-dried
gastric injury
histopathologic analysis
hydroxypropyl-b-cyclodextrin complex
indomethacin
spray-dried
Online Access:http://hdl.handle.net/10316/101116
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/101116

Internet

http://hdl.handle.net/10316/101116

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