O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer

ST6GalNAc-I, the sialyltransferase responsible for sialyl-Tn (sTn) synthesis, has been previously reported to be positively associated with cancer aggressiveness. Here we describe a novel sTn-dependent mechanism for chemotherapeutic resistance. We show that sTn protects cancer cells against chemothe...

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Detalhes bibliográficos
Autor principal: Sofia mN. Santos (author)
Outros Autores: Mara S. Junqueira (author), Guilherme Francisco (author), Manuel Vilanova (author), Ana Magalhães (author), Marcelo Dias Baruffi (author), Roger Chammas (author), Adrian L. Harris (author), Celso Reis (author), Emerson S. Bernardes (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Medicina, Ciências médicas e da saúde
Medicine, Medical and Health sciences
Texto completo:https://hdl.handle.net/10216/90888
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/90888

Texto Completo

https://hdl.handle.net/10216/90888

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