O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer

ST6GalNAc-I, the sialyltransferase responsible for sialyl-Tn (sTn) synthesis, has been previously reported to be positively associated with cancer aggressiveness. Here we describe a novel sTn-dependent mechanism for chemotherapeutic resistance. We show that sTn protects cancer cells against chemothe...

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Bibliographic Details
Main Author: Sofia mN. Santos (author)
Other Authors: Mara S. Junqueira (author), Guilherme Francisco (author), Manuel Vilanova (author), Ana Magalhães (author), Marcelo Dias Baruffi (author), Roger Chammas (author), Adrian L. Harris (author), Celso Reis (author), Emerson S. Bernardes (author)
Format: article
Language:eng
Published: 2016
Subjects:
Medicina, Ciências médicas e da saúde
Medicine, Medical and Health sciences
Online Access:https://hdl.handle.net/10216/90888
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/90888

Internet

https://hdl.handle.net/10216/90888

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