Use of half-generation PAMAM dendrimers (G0. 5–G3. 5) with carboxylate end-groups to improve the DACHPtCl2 and 5-FU efficacy as anticancer drugs

The DACHPtCl2 compound (trans-(R,R)-1,2-diaminocyclohexanedichloroplatinum(II)) is a potent anticancer drug with a broad spectrum of activity and is less toxic than oxaliplatin (trans-l-diaminocyclohexane oxalate platinum II), with which it shares the active metal fragment DACHPt. Nevertheless, due...

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Bibliographic Details
Main Author: Camacho, Cláudia (author)
Other Authors: Tomás, Helena (author), Rodrigues, João (author)
Format: article
Language:eng
Published: 2022
Subjects:
Dendrimers
PAMAM
Anticancer drugs
Metallodrugs
Oxaliplatin
5-FU
.
Faculdade de Ciências Exatas e da Engenharia
Online Access:http://hdl.handle.net/10400.13/4086
Country:Portugal
Oai:oai:digituma.uma.pt:10400.13/4086

Internet

http://hdl.handle.net/10400.13/4086

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