Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis

OBJECTIVE: CD8+ T cells are part of the T cell pool infiltrating the synovium in rheumatoid arthritis (RA). However, their role in the pathogenesis of RA has not been fully delineated. Using the K/BxN mouse model of spontaneous chronic arthritis, which shares many similarities with RA, we studied th...

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Bibliographic Details
Main Author: Raposo, BR (author)
Other Authors: Rodrigues-Santos, P (author), Carvalheiro, H (author), Água-Doce, AM (author), Carvalho, L (author), Pereira da Silva, JA (author), Graça, L (author), Souto-Carneiro, MM (author)
Format: article
Language:eng
Published: 2011
Subjects:
Artrite Experimental
Antigénio CD8
Anticorpos Monoclonais
Online Access:http://hdl.handle.net/10400.4/1111
Country:Portugal
Oai:oai:rihuc.huc.min-saude.pt:10400.4/1111

Internet

http://hdl.handle.net/10400.4/1111

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