Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction

Aim Chalcones are naturally occurring compounds with recognized anticancer activity. It was recently shown that the O-prenyl derivative (2) of 2-hydroxy-3,4,4,5,6-pentamethoxychalcone (1) had a remarkably increased cytotoxicity against human tumour cells compared to its precursor. With this study, w...

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Bibliographic Details
Main Author: Leão, M (author)
Other Authors: Soares, J (author), Gomes, S (author), Raimundo, L (author), Ramos, H (author), Bessa, C (author), Queiroz, G (author), Domingos, S (author), Pinto, M (author), Inga, A (author), Honorina Cidade (author), Lucilia Saraiva (author)
Format: article
Language:eng
Published: 2015
Online Access:https://repositorio-aberto.up.pt/handle/10216/91106
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/91106

Internet

https://repositorio-aberto.up.pt/handle/10216/91106

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