Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors

The synthesis and biological evaluation of novel 1-aryl-3-[2-, 3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl] ureas 3, 4 and 5 as VEGFR-2 tyrosine kinase inhibitors, are reported. The 1-aryl-3-[3-(thieno[3,2-b]- pyridin-7-ylthio)phenyl]ureas 4a–4h, with the arylurea in the meta position to the thioe...

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Bibliographic Details
Main Author: Machado, Vera A. (author)
Other Authors: Peixoto, Daniela (author), Costa, Raquel (author), Froufe, Hugo J.C. (author), Calhelha, Ricardo C. (author), Abreu, Rui M.V. (author), Ferreira, Isabel C.F.R. (author), Soares, Raquel (author), Queiroz, Maria João R.P. (author)
Format: article
Language:eng
Published: 2015
Subjects:
Thienopyridinethioether 1,3-diarylureas
VEGFR-2 tyrosine kinase inhibitors
Enzymatic assays
Molecular docking
HUVECs
Antiangiogenesis assays
Western blotting
Online Access:http://hdl.handle.net/10198/12461
Country:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/12461

Internet

http://hdl.handle.net/10198/12461

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