The mutational spectrum of WT1 in male infertility

PURPOSE: We evaluated the impact of WT1 mutations in isolated severe spermatogenic impairment in a population of European ancestry. WT1 was first identified as the gene responsible for Wilms tumor. It was later associated with a plethora of clinical phenotypes often accompanied by urogenital defects...

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Bibliographic Details
Main Author: Seabra, Catarina M. (author)
Other Authors: Quental, Sofia (author), Lima, Ana C (author), Carvalho, Filipa (author), Gonçalves, João (author), Fernandes, Susana (author), Pereira, Iris (author), Silva, Júlia (author), Marques, Patrícia I. (author), Sousa, Mário (author), Barros, Alberto (author), Seixas, Susana (author), Amorim, António (author), Lopes, Alexandra M. (author)
Format: article
Language:eng
Published: 2015
Subjects:
WT1
Infertility
Doenças Genéticas
Male Infertility
Spermatogenesis
Wilms Tumor
European Continental Ancestry Group
Genes
Mutation
Testis
Online Access:http://hdl.handle.net/10400.18/2710
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/2710

Internet

http://hdl.handle.net/10400.18/2710

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