Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease

Histone deacetylases (HDACs) are key epigenetic enzymes and emerging drug targets in cancer and neurodegeneration. Pan-HDAC inhibitors provided neuroprotection in Parkinson's Disease (PD) models, however, the HDAC isoforms with highest neuroprotective potential remain unknown. Zebrafish larvae...

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Bibliographic Details
Main Author: Brígida R Pinho (author)
Other Authors: Sara D Reis (author), Pedro Guedes-Dias (author), Ana Leitão-Rocha (author), Clara Quintas (author), Patrícia Valentão (author), Paula B Andrade (author), Miguel M Santos (author), Jorge M.A Oliveira (author)
Format: article
Language:eng
Published: 2016
Subjects:
Ciências farmacológicas, Neurociências, Ciências da saúde
Pharmacological sciences, Neuroscience, Health sciences
Online Access:https://hdl.handle.net/10216/105015
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/105015

Internet

https://hdl.handle.net/10216/105015

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