Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia

Bacterial septicaemia is a major cause of mortality, but its pathogenesis remains poorly understood. In experimental pneumococcal murine intravenous infection, an initial reduction of bacteria in the blood is followed hours later by a fatal septicaemia. These events represent a population bottleneck...

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Bibliographic Details
Main Author: Ercoli, Giuseppe (author)
Other Authors: Fernandes, Vitor E. (author), Chung, Wen Y. (author), Wanford, Joseph J. (author), Thomson, Sarah (author), Bayliss, Christopher D. (author), Straatman, Kornelis (author), Crocker, Paul R. (author), Dennison, Ashley (author), Martinez-Pomares, Luisa (author), Andrew, Peter W. (author), Moxon, E. Richard (author), Oggioni, Marco R. (author)
Format: article
Language:eng
Published: 2018
Subjects:
Bacterial infection
Bacterial pathogenesis
Infection
Pathogens
Online Access:http://hdl.handle.net/10400.1/10654
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/10654

Internet

http://hdl.handle.net/10400.1/10654

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