Trehalose alleviates the phenotype of Machado–Joseph disease mouse models

Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration. There is no treatment available to block or delay disease progression. In this wo...

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Bibliographic Details
Main Author: Santana, Magda M. (author)
Other Authors: Paixão, Susana (author), Cunha-Santos, Janete (author), Silva, Teresa Pereira (author), Trevino-Garcia, Allyson (author), Gaspar, Laetitia S. (author), Nóbrega, Clévio (author), Nobre, Rui Jorge (author), Cavadas, Cláudia (author), Greif, Hagar (author), Pereira de Almeida, Luís (author)
Format: article
Language:eng
Published: 2020
Subjects:
Machado-Joseph disease
Autophagy
Spinocerebellar ataxia type 3
Polyglutamine disorder
Trehalose
Online Access:http://hdl.handle.net/10400.1/13814
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/13814

Internet

http://hdl.handle.net/10400.1/13814

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