Cytochrome 1A1 and 1B1 gene diversity in the Zanzibar islands

Amodiaquine (AQ) is a 4-aminoquinoline widely used in the treatment of malaria as part of the artemisinin combination therapy (ACT). AQ is metabolised towards its main metabolite desethylamodiaquine mainly by cytochrome P450 2C8 (CYP2C8). CYP1A1 and CYP1B1 play a minor role in the metabolism but the...

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Bibliographic Details
Main Author: Cavaco, I. (author)
Other Authors: Piedade, R. (author), Msellem, M. I. (author), Bjorkman, A. (author), Gil, José Pedro (author)
Format: article
Language:eng
Published: 2018
Subjects:
Functional-analysis
Malaria patients
Breast-cancer
Amodiaquine
Polymorphism
Metabolism
Bioactivation
Leukocytes
Variants
Receptor
Online Access:http://hdl.handle.net/10400.1/11469
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/11469

Internet

http://hdl.handle.net/10400.1/11469

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