Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts

During myocardial ischemia and reperfusion both purines and pyrimidines are released into the extracellular milieu, thus creating a signaling wave that propagates to neighboring cells via membrane-bound P2 purinoceptors activation. Cardiac fibroblasts (CF) are important players in heart remodeling,...

Full description

Bibliographic Details
Main Author: Certal, Mariana (author)
Other Authors: Vinhas, Adriana (author), Pinheiro, Ana Rita (author), Ferreirinha, Fátima (author), Barros-Barbosa, Aurora Raquel (author), Silva, Isabel (author), Costa, Maria Adelina (author), Correia-de-Sá, Paulo (author)
Format: article
Language:eng
Published: 2016
Subjects:
Cardiac fibroblasts
Myofibroblast
UTP
P2Y2 receptor
P2Y4 receptor
P2Y11 receptor
Intracellular calcium
Fibroblast cell growth
ATP release
CX43-containing hemichannels
Adenylate cyclase
Cyclic AMP
EPAC
Online Access:http://hdl.handle.net/10400.22/7543
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/7543

Internet

http://hdl.handle.net/10400.22/7543

Similar Items