PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia

Drug delivery to the central nervous system is restricted by the blood-brain barrier (BBB). However, with the onset of stroke, the BBB becomes leaky, providing a window of opportunity to passively target the brain. Here, cationic poly(amido amine) (PAMAM) dendrimers of different generations were fun...

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Detalhes bibliográficos
Autor principal: Santos, SD (author)
Outros Autores: Xavier, M (author), Leite, D (author), Moreira, D (author), Custódio, B (author), Torrado, M (author), Castro, R (author), Leiro, V (author), Rodrigues, J (author), Tomás, H (author), Pêgo, AP (author)
Formato: article
Idioma:eng
Publicado em: 2018
Texto completo:https://hdl.handle.net/10216/121134
País:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/121134

Texto Completo

https://hdl.handle.net/10216/121134

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