Stimulation of RAC1/PAK1 signalling upregulates DNA damage repair genes via STAT5 stimulation of BCL6 repressed loci

Colorectal cancer is one of the most prevalent types of cancer worldwide. The GTPase RAC1 and its effector PAK1 have been found overexpressed or hyperactivated in colorectal cancers, particularly those with more aggressive and invasive features, leading to unfavourable clinical prognosis, often resu...

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Bibliographic Details
Main Author: Barros, Patricia (author)
Other Authors: Amaral, Andreia (author), Abrantes, Leonor (author), Oliveira, Tiago (author), Louro, Henriqueta (author), Silva, Maria joão (author), Jordan, Peter (author), Gama-Carvalho, Margarida (author), Matos, Paulo (author)
Format: conferenceObject
Language:eng
Published: 2020
Subjects:
Colorectal Cancer
BCL6
RAC1
DNA Damage
Vias de Transdução de Sinal e Patologias Associadas
Online Access:http://hdl.handle.net/10400.18/5797
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5797

Internet

http://hdl.handle.net/10400.18/5797

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