Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase

Rab geranylgeranyl transferase (RGGT) catalyzes the posttranslational geranylgeranyl (GG) modification of (usually) two C-terminal cysteines in Rab GTPases. Here we studied the mechanism of the Rab geranylgeranylation reaction by bisphosphonate analogs in which one phosphonate group is replaced by a...

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Bibliographic Details
Main Author: Baron, Rudi A. (author)
Other Authors: Tavaré, Richard (author), Figueiredo, Ana C. (author), Błazewska, Katarzyna M. (author), Kashemirov, Boris A. (author), McKenna, Charles E. (author), Ebetino, Frank H. (author), Taylor, Adam (author), Rogers, MIchael J. (author), Coxon, Fraser P. (author), Seabra, Miguel C. (author)
Format: article
Language:eng
Published: 2022
Subjects:
Biochemistry
Molecular Biology
Cell Biology
Online Access:http://hdl.handle.net/10362/142325
Country:Portugal
Oai:oai:run.unl.pt:10362/142325

Internet

http://hdl.handle.net/10362/142325

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