Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase

Rab geranylgeranyl transferase (RGGT) catalyzes the posttranslational geranylgeranyl (GG) modification of (usually) two C-terminal cysteines in Rab GTPases. Here we studied the mechanism of the Rab geranylgeranylation reaction by bisphosphonate analogs in which one phosphonate group is replaced by a...

ver descrição completa

Detalhes bibliográficos
Autor principal: Baron, Rudi A. (author)
Outros Autores: Tavaré, Richard (author), Figueiredo, Ana C. (author), Błazewska, Katarzyna M. (author), Kashemirov, Boris A. (author), McKenna, Charles E. (author), Ebetino, Frank H. (author), Taylor, Adam (author), Rogers, MIchael J. (author), Coxon, Fraser P. (author), Seabra, Miguel C. (author)
Formato: article
Idioma:eng
Publicado em: 2022
Assuntos:
Biochemistry
Molecular Biology
Cell Biology
Texto completo:http://hdl.handle.net/10362/142325
País:Portugal
Oai:oai:run.unl.pt:10362/142325

Texto Completo

http://hdl.handle.net/10362/142325

Registros relacionados