Medicinal Chemistry Strategies to Disrupt the p53–MDM2/MDMX Interaction
The growth inhibitory activity of p53 tumor suppressor is tightly regulated by interaction with two negative regulatory proteins, murine double minute 2 (MDM2) and X (MDMX), which are overexpressed in about half of all human tumors. The elucidation of crystallographic structures of MDM2/MDMX complex...
| Autor principal: | |
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| Outros Autores: | , , , , , |
| Formato: | article |
| Idioma: | eng |
| Publicado em: |
2016
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| Texto completo: | https://hdl.handle.net/10216/120356 |
| País: | Portugal |
| Oai: | oai:repositorio-aberto.up.pt:10216/120356 |