Medicinal Chemistry Strategies to Disrupt the p53–MDM2/MDMX Interaction

The growth inhibitory activity of p53 tumor suppressor is tightly regulated by interaction with two negative regulatory proteins, murine double minute 2 (MDM2) and X (MDMX), which are overexpressed in about half of all human tumors. The elucidation of crystallographic structures of MDM2/MDMX complex...

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Bibliographic Details
Main Author: Lemos A. (author)
Other Authors: Leão M. (author), Soares J. (author), Palmeira A. (author), Pinto M. (author), Saraiva L. (author), Sousa M.E. (author)
Format: article
Language:eng
Published: 2016
Online Access:https://hdl.handle.net/10216/120356
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/120356

Internet

https://hdl.handle.net/10216/120356

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