Antisense Oligonucleotides Modulating Activation of a Nonsense-Mediated RNA Decay Switch Exon in the ATM Gene

ATM (ataxia-telangiectasia, mutated) is an important cancer susceptibility gene that encodes a key apical kin ase in the DNA damage response pathway. ATM mutations in the germ line result in ataxia-telangiectasia (A-T), a rare genetic syndrome associated with hypersensitivity to double-strand DNA br...

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Bibliographic Details
Main Author: Kralovicova, J (author)
Other Authors: Moreno, PM (author), Cross, N (author), Pêgo, AP (author), Vorechovsky, I (author)
Format: article
Language:eng
Published: 2016
Subjects:
alternative splicing
antisense oligonucleotides
ATM
lymphoid cancer
nanoparticles
nonsense-mediated RNA decay
transposon
Online Access:https://hdl.handle.net/10216/120743
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/120743

Internet

https://hdl.handle.net/10216/120743

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