Contribution of TRNA modifications for proteostasis in human cells
Mutations in transfer RNAs (tRNA), key molecules in the translation process, lead to loss of accuracy of messenger RNA (mRNA) translation. This may induce changes in protein synthesis rate, protein misfolding and accumulation of aggregated proteins which, in turn, leads to proteotoxic stress and UPR...
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| Format: | masterThesis |
| Language: | eng |
| Published: |
2020
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| Online Access: | http://hdl.handle.net/10773/24859 |
| Country: | Portugal |
| Oai: | oai:ria.ua.pt:10773/24859 |