Epitope mapping of a new anti-Tn antibody detecting gastric cancer cells.

Here, we introduce a novel scFv antibody, G2-D11, specific for two adjacent Tn-antigens (GalNAc- Ser/Thr) binding equally to three dimeric forms of the epitope, Ser-Thr, Thr-Thr and Thr-Ser. Compared to other anti-Tn reagents, the binding of G2-D11 is minimally influenced by the peptide structure, w...

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Bibliographic Details
Main Author: Persson, N (author)
Other Authors: Stuhr-Hansen, N (author), Risinger, C (author), Mereiter, S (author), Polónia, A (author), Polom, K (author), Kovács, A (author), Roviello, F (author), Reis, CA (author), Welinder, C (author), Danielsson, L (author), Jansson, B (author), Blixt, O (author)
Format: article
Language:eng
Published: 2017
Subjects:
Antigens, Tumor-Associated, Carbohydrate/chemistry
Antigens, Tumor-Associated, Carbohydrate/immunology
Carcinoma/metabolism
Carcinoma/pathology
Cell Line, Tumor
Epitope Mapping
Epitopes/chemistry
Epitopes/immunology
Humans
Single-Chain Antibodies/chemistry
Single-Chain Antibodies/immunology
Stomach Neoplasms/metabolism
Stomach Neoplasms/pathology
Online Access:https://hdl.handle.net/10216/119041
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/119041

Internet

https://hdl.handle.net/10216/119041

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