Stratified 3D microtumors as organotypic testing platforms for screening pancreatic cancer therapies

Cancer-associated pancreatic stellate cells installed in periacinar/periductal regions are master players in generating the characteristic biophysical shield found in pancreatic ductal adenocarcinoma (PDAC). Recreating this unique PDAC stromal architecture and its desmoplastic microenvironment in vi...

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Bibliographic Details
Main Author: Monteiro, Maria V. (author)
Other Authors: Gaspar, Vítor M. (author), Mendes, Luís (author), Duarte, Iola F. (author), Mano, João F. (author)
Format: article
Language:eng
Published: 2022
Subjects:
Biomimetic 3D tumor models
ECM mimetic biomaterials
Pancreatic cancer
Preclinical testing platforms
Tumor microenvironment
Online Access:http://hdl.handle.net/10773/34744
Country:Portugal
Oai:oai:ria.ua.pt:10773/34744

Internet

http://hdl.handle.net/10773/34744

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